Melt Extrusion by Michael A. Repka Nigel Langley & James DiNunzio

Author:Michael A. Repka, Nigel Langley & James DiNunzio
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

The peak at 178.9 ppm corresponding to citric acid monohydrate was followed to determine the extent of conversion to the cocrystal. These data clearly show that conversion, scales as TC1 < TC3 < TC2 < TC4 = TC5. Thus, as seen in the previous case study with carbamazepine and saccharin, liquid-assisted extrusion was able to facilitate cocrystal formation at lower temperatures and resulted in an increased extent of conversion when compared to neat extrusion. These findings using TSE nicely paralleled those observed with grinding experiments.

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